Search Result

Search Results for " glutathione s-transferase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11505	GSTO1-IN-1		Glutathione Peroxidase , GST
	GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).		Glutathione Peroxidase , GST
T4564	Ethacrynic acid	Edecrin,Etacrynic Acid,Hydromedin	Others , Calcium Channel , NF-κB , GST
	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase a...		Others , Calcium Channel , NF-κB , GST
T5097	Ezatiostat	TER199(free base),TLK199	Apoptosis , Glutathione Peroxidase , GST
	Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.		Apoptosis , Glutathione Peroxidase , GST
T22776	Ezatiostat hydrochloride	TLK199 HCl,TER199	Glutathione Peroxidase
	Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydr...		Glutathione Peroxidase
T5862	Ezatiostat TFA	TER199(free base),Ezatiostat TFA (free base),Ezatiostat,TLK199	GST
	Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.		GST
T24807	S-Methylglutathione	Glutathione S-methyl ester,Glutathione ester,S-Methyl glutathione	Glyoxalase
	S-Methylglutathione (S-Methyl glutathione) is an S-substituted glutathione, an inhibitor of the 1-chloro-2,4-dinitrobenzene coupling catalyzed by transferase A and an XOCl scavenger.S-Methylglutathione inhibits glyoxalas...		Glyoxalase
T12189	NBDHEX		Apoptosis , Glutathione Peroxidase , Autophagy
	NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) .		Apoptosis , Glutathione Peroxidase , Autophagy
T0153	Oltipraz	NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
T23929	Cysfluoretin
	Cysfluoretin has glutathione S-transferase inhibitory activity.
T25160	BITC-SG
	BITC-SG inhibits human glutathione S-transferase P1-1 by S-thiocarbamoylation.
T27541	Hexylglutathione	NSC 131114,NSC-131114,NSC131114,S-Hexylglutathione
	Hexylglutathione, a glutathione-S-transferase inhibitor, is used to study the effects of phase II enzymes and glutathione.
T26374	(S)-alpha-Fluoromethylhistidine 2 HCl
	(S)-alpha-Fluoromethylhistidine 2 HCl is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase.
T8424	TLK117	TER117	Others
	TLK117 selective inhibits Glutathione S-transferase P1–1 (GSTP1-1)(Ki of 0.4 μM for GSTP).		Others
T11504	GSTO-IN-2		Others
	GSTO-IN-2 is a glutathione S-transferase inhibitor (IC50s: 1.4, 16.3, and 3.6 μM for GSTP1-1, GSTM1, and GSTA2).		Others
T81136	S-Octylglutathione
	S-Octylglutathione is a competitive inhibitor of glutathione S-transferase (GST) [1].
T39906	LAS17	LAS17
	LAS17, a potent and selective irreversible inhibitor targeting tyrosine in glutathione S-Transferase Pi (GSTP1), effectively inhibits GSTP1 activity, demonstrated by an IC50 value of 0.5 μM.
T68464	PABA/NO
	PABA/NO is a novel glutathione-S-transferase-p-activated nitric oxide donor, inhibiting proliferation and inducing apoptosis by targeting PI3K/AKT/mTOR and MEK/ERK pathways in hepatocellular carcinoma cells.
T78800	GST-IN-1
	GST-IN-1, also known as compound 16, is a potent inhibitor of glutathione S-transferase (GST), exhibiting inhibitory concentration 50 (IC50) values of 1.55 μM for sjGST and 2.02 μM for hGSTM2.
T72328	Cyclopropenone probe 1
	Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1) , by covalently binding at the catalytic active site.
T37301	PCTR2
	Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutath...
T75245	Canfosfamide
	Canfosfamide (TLK-286, TER286), a glutathione analogue prodrug, becomes activated by glutathione S-transferase P1-1 to induce apoptosis and inhibit DNA-dependent protein kinase's (DNA-PK) catalytic kinase activity. Upon ...
T35979	Benastatin C
	Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Be...
T70798	Benastatin B
	Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Bena...
T67975	Canfosfamide hydrochloride
	Canfosfamide Hydrochloride is the hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating m...
T35978	Benastatin A
	Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benast...
T37302	PCTR3
	Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutath...
T37300	PCTR1	PCTR1
	Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by ...
T36170	A1-Phytoprostane-I	A1-Phytoprostane-I
	A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants. There are two A1-phytoprostanes, both having the single ketone group on the ring structu...
T37506	MCTR2	MCTR2
	Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is ...
T36074	S-NEPC
	Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) cata...
T69978	Brostallicin HCl
	Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having form...
T37507	MCTR3	MCTR3
	Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutat...
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9 (compound 11) is a potent inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI) with an IC50 value of 0.575 µM. It enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1),...
T37505	MCTR1	MCTR1
	Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is ...
T68581	AP23464
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ab...

Compounds

GSTO1-IN-1

T11505

Synonym:

Target: Glutathione Peroxidase, GST

Ethacrynic acid

T4564

Synonym: Edecrin,Etacrynic Acid,Hydromedin

Target: Others, Calcium Channel, NF-κB, GST

Ezatiostat

T5097

Synonym: TER199(free base),TLK199

Target: Apoptosis, Glutathione Peroxidase, GST

Ezatiostat hydrochloride

T22776

Synonym: TLK199 HCl,TER199

Target: Glutathione Peroxidase

Ezatiostat TFA

T5862

Synonym: TER199(free base),Ezatiostat TFA (free base),Ezatiostat,TLK199

Target: GST

S-Methylglutathione

T24807

Synonym: Glutathione S-methyl ester,Glutathione ester,S-Methyl glutathione

Target: Apoptosis, Glutathione Peroxidase, Autophagy

Oltipraz

T0153

Synonym: NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Synonym: NSC 131114,NSC-131114,NSC131114,S-Hexylglutathione

Target:

(S)-alpha-Fluoromethylhistidine 2 HCl

Cyclopropenone probe 1

canfosfamide hydrochloride

Synonym: A1-Phytoprostane-I

Cat No.	Product Name	Synonyms	Targets
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST
TN1078	Seneciphylline		P450 , GST
	Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat...		P450 , GST
T7995	α-Angelica lactone	Alpha-Angelica Lactone	Others , GST
	α-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.		Others , GST
T3S0541	Curzerene		Apoptosis , GST
	Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apoptosis in cells[1] and also suppress the expression of glutat...		Apoptosis , GST
T5654	Musk ketone		Others
	Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.		Others
T11680	Isoasatone A		P450
	Isoasatone A is a natural product isolated from the plant Heterotropa takaoi M., with anti-insect activity.		P450
T3S0218	Thonningianin A		Apoptosis , Others
	1. Thonningianin A has anti-cancer activities.2. Thonningianin A represents a new potent glutathione S-transferase in vitro inhibitor.3. Thonningianin A has antioxidant property, involves radical scavenging, anti-superox...		Apoptosis , Others
T6S0071	Fraxinellone		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
TN2849	3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid		Antifection
	2-O-beta-d-Glucosyloxy-4-methoxybenzenepropanoic acid[3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid] exhibits glutathione S-transferase (GST) inhibitory and antifungal activities.		Antifection
TN4345	Jacobine		Others
	Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.		Others

Natural Products

Synonym: Alpha-Angelica Lactone

Target: Apoptosis, GST

Target: Apoptosis, Others

Fraxinellone

T6S0071

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00539	GSTA1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds. Glutathione S-transferases (GSTs) ...
TMPY-03450	GSTK1 Protein, Human, Recombinant	Human	E. coli
	GSTK1 gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a var...
TMPY-00027	GSTT2B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	GSTT2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is P0CG29.
TMPY-03338	GSTZ1 Protein, Human, Recombinant (His)	Human	E. coli
	GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes mult...
TMPY-01554	GSTM5 Protein, Human, Recombinant (His)	Human	E. coli
	GSTM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.9 kDa and the accession number is AAH58881.1.
TMPY-02223	GSTM2 Protein, Human, Recombinant (His)	Human	E. coli
	Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-te...
TMPJ-00499	GSTP1 Protein, Human, Recombinant	Human	E. coli
	Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in deto...
TMPJ-00690	PGDS Protein, Human, Recombinant	Human	E. coli
	Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macroph...
TMPY-02157	GST Protein, Schistosoma japonicum, Recombinant	Schistosoma japonicum	Baculovirus Insect Cells
	Genetic engineers have used glutathione S-transferase to create the GST gene fusion system. This system is used to purify and detect proteins of interest. In a GST gene fusion system, the GST sequence is incorporated int...
TMPY-01480	LTC4S Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous...